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KMID : 0369819930230040217
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Jorunal of Korean Pharmaceutical Sciences
1993 Volume.23 No. 4 p.217 ~ p.223
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In vitro and In Vivo Evaluation of the Combined Products of Antacid and Anti - ulcer Drug
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김종국/Kim CK
안혜진/정은주/오경희/나운용/Ahn HJ/Jeong EJ/Oh KH/Lah WL
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Abstract
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The combined products of antacid and anti-ulcer agent were prepared with antacid composed of aluminium hydroxide dried gel, magnesium hydroxide and simethicone with a ratio of 1:1:0.1 (M) and anti-ulcer agent, aceglutamide aluminium (AGA). The efficacy of antacid was evaluated in vitro with Fuchs, Johnson-Duncan and Rosset-Rice methods and in vivo using an aspiration method in rat. The addition of anti-ulcer agent did not affect the neutralizing capacity of M significantly. The combined products with the M/AGA ratios of 2.3:1 and 3.4:1 produced the maximum pH of 4.0∼5.8 and the duration time of 64∼137 min in vitro test. The in vivo neutralizing test in rats showed the rapid increase of gastric pH up to 3.5 within 30 min and the gastric pH of 4∼6 was kept for 5 hr.
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KEYWORD
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Antacid, Anti-ulcer agent, Aceglutamide aluminium, Reaction time, Neutralizing capacity, Duration time, in vitro Evaluation of antacid, in vivo Evaluation of antacid
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